Week of Sept. 29, 2007; Vol. 172, No. 13
It's hard to avoid bisphenol A. One of the highest-volume chemicals in commercial production, it's the starting material used to make polycarbonate plastics. Those are the hard, clear plastics used in baby bottles, flatware, watercooler bottles, and the work bowls of food processors. Bisphenol A (BPA) also serves as an essential ingredient of epoxy resins used to line food and beverage cans and even to seal cavity-prone teeth.
PLASTIC? OH NO! Plastic household products that are hard and clear are typically made of polycarbonate plastic, which tends to leach bisphenol A with age and after heating. When the plastic crackles, as often happens, the leaching accelerates. Raloff
But BPA doesn't stay put. It inevitably leaches into foods and people's mouths, such that traces of the chemical now show up in everyone's body.
The universal presence of BPA has raised concerns because hundreds of animal studies have shown that this largely unregulated pollutant can tinker with the development and function of a wide range of tissues. These studies show, among other effects, that BPA can alter rodents' and other lab animals' sex-specific behaviors, perturb developmentally important hormones, boost fat cell numbers and their accumulation of lipids, foster precancerous changes in cells, and induce insulin resistance, a harbinger of diabetes.
If all of this happens in animals, can any of it happen in people too?
That's what the National Institute of Environmental Health Sciences decided to investigate, explains Jerrold J. Heindel, who works at the institute in Research Triangle Park, N.C. Two years ago, its National Toxicology Program (NTP) recruited two panels of experts to review masses of data on BPA's reproductive and developmental effects. Last month, these panels issued reports offering different âand in some ways conflictingâassessments. One panel found many areas of concern. The other turned up few.
Ultimately, NTP will issue a single report that integrates conclusions from both panels, along with any new information on BPA that comes to light during the next few months. That report probably won't emerge for at least a year, says the institute's Michael D. Shelby, whose office will prepare the final document.
In the meantime, how worried should consumers be?
Previous evaluations "support the conclusion that BPA is not a risk to human health at the extremely low levels to which consumers might be exposed," according to a statement issued last month by the American Chemistry Council, a chemical-industry group based in Arlington, Va. It interpreted a recent report on BPA by the European Food Safety Authority as indicating that "consumers are not at risk from use of products made from BPA."
Such reassurances don't satisfy a number of BPA researchers, howeverâamong them Randy Jirtle of Duke University in Durham, N.C. He recently published a rodent study showing that fetal BPA exposure can reprogram lifelong gene activity in the agouti breed of mice and even change the animals' coat colors (SN: 8/11/07, p. 84). Those data alone prompt Jirtle to say that "if I was a woman who was pregnantâor thinking about becoming pregnantâI would try hard to avoid exposure to BPA."
The chasm between such opinions explains why NTP's judgment is so eagerly awaited. Moreover, Heindel says, it emphasizes why human studies that can confirm or refute BPA effects seen in animals and test tubes must become a research priority.